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Article

Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway.

Archives of biochemistry and biophysics - 15 Sept 2018

Lim Ji Ye, Liu Chun, Hu Kang-Quan, Smith Donald E, Wang Xiang-Dong

Abstract excerpt

β-Carotene-15, 15'-oxygenase (BCO1) and β-carotene-9', 10'-oxygenase (BCO2) are essential enzymes in carotenoid metabolism. While BCO1/BCO2 polymorphisms have been associated with alterations to human and animal carotenoid levels, experimental studies have suggested that BCO1 and BCO2 may have specific physiological functions beyond the cleavage of carotenoids. In the present study, we investigated the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30006135
DOI: 10.1016/j.abb.2018.07.007

Genes

BCO1
BCO2
SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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