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Article

Role of Mitochondrial Complex IV in Age-Dependent Obesity

1 Sept 2016

Abstract excerpt

Aging is associated with progressive white adipose tissue (WAT) enlargement initiated early in life, but the molecular mechanisms involved remain unknown. Here we show that mitochondrial complex IV (CIV) activity and assembly are already repressed in white adipocytes of middle-aged mice and involve a HIF1A-dependent decline of essential CIV components such as COX5B. At the molecular level, HIF1A binds to the...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Identifiers

PMID: 27626667
DOI: 10.1016/j.celrep.2016.08.041

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