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Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes

4 Nov 2022

Abstract excerpt

Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue remain unclear. Here, we demonstrate that Park2 gene (encodes Parkin) deletion specifically from adipose tissue protects mice against high-fat diet and aging-induced obesity. Despite a mild reduction in...

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PMID: 36333379
DOI: 10.1038/s41467-022-34468-2

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