Article
Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.
American journal of respiratory cell and molecular biology - 1 Nov 2014
McDonald Merry-Lynn N, Cho Michael H, Sørheim Inga-Cecilie, Lutz Sharon M, Castaldi Peter J, Lomas David A, Coxson Harvey O, Edwards Lisa D, MacNee William, Vestbo Jørgen, Yates Julie C, Agusti Alvar, Calverley Peter M A, Celli Bartolome, Crim Courtney, Rennard Stephen I, Wouters Emiel F M, Bakke Per, Tal-Singer Ruth, Miller Bruce E, Gulsvik Amund, Casaburi Richard, Wells J Michael, Regan Elizabeth A, Make Barry J, Hokanson John E, Lange Christoph, Crapo James D, Beaty Terri H, Silverman Edwin K, Hersh Craig P
Abstract excerpt
Hypoxemia is a major complication of chronic obstructive pulmonary disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among patients with COPD. However, previous genetic studies have been restricted to investigating COPD candidate genes for association with hypoxemia. To report results...
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