Inhibition of Ca(2+) release-activated Ca(2+) channel (CRAC) by curcumin and caffeic acid phenethyl ester (CAPE) via electrophilic addition to a cysteine residue of Orai1.

Abstract excerpt

Ca(2+) influx through Ca(2+)-release activated Ca(2+) channels (CRAC) is critical for activating immune cells. Orai and STIM proteins comprise the molecular components of CRAC. We previously observed that curcumin and caffeic acid phenethyl ester (CAPE) inhibit CRAC current in Orai1/STIM1-co-expressing HEK293 cells (Nam et al., 2009; Shin et al., 2011) [1,2]. Both compounds contain electrophilic α,β-unsaturated...

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