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Article

State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation.

The Journal of general physiology - 1 May 2014

Amcheslavsky Anna, Safrina Olga, Cahalan Michael D

Abstract excerpt

After endoplasmic reticulum (ER) Ca(2+) store depletion, Orai channels in the plasma membrane (PM) are activated directly by ER-resident stromal interacting molecule (STIM) proteins to form the Ca(2+)-selective Ca(2+) release-activated Ca(2+) (CRAC) channel. Of the three human Orai channel homologues, only Orai3 can be activated by high concentrations (>50 µM) of 2-aminoethyl diphenylborinate (2-APB). 2-APB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24733836
DOI: 10.1085/jgp.201411171
PMCID: PMC4003185

Genes

STIM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation.PMID 24733836Read ↗

2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.Semantic proximity Read ↗

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels.Semantic proximity Read ↗

Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.Semantic proximity Read ↗

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.Semantic proximity Read ↗

The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties.Semantic proximity Read ↗

ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domainSemantic proximity Read ↗

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.Semantic proximity Read ↗

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.Semantic proximity Read ↗

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Semantic proximity Read ↗

Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated stateSemantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

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