Article
Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.
PLoS genetics - 1 Sept 2016
Verma Shefali Setia, Cooke Bailey Jessica N, Lucas Anastasia, Bradford Yuki, Linneman James G, Hauser Michael A, Pasquale Louis R, Peissig Peggy L, Brilliant Murray H, McCarty Catherine A, Haines Jonathan L, Wiggs Janey L, Vrabec Tamara R, Tromp Gerard, Ritchie Marylyn D
Abstract excerpt
Primary open angle glaucoma (POAG) is a complex disease and is one of the major leading causes of blindness worldwide. Genome-wide association studies have successfully identified several common variants associated with glaucoma; however, most of these variants only explain a small proportion of the genetic risk. Apart from the standard approach to identify main effects of variants across the genome, it is...
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