Article
The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.
Journal of glaucoma - 1 Sept 2013
Wiggs Janey L, Hauser Michael A, Abdrabou Wael, Allingham Robert Rand, Budenz Donald L, Delbono Elizabeth, Friedman David S, Kang Jae H, Gaasterland Douglas, Gaasterland Terry, Lee Richard K, Lichter Paul R, Loomis Stephanie, Liu Yutao, McCarty Cathy, Medeiros Felipe A, Moroi Sayoko E, Olson Lana M, Realini Anthony, Richards Julia E, Rozsa Frank W, Schuman Joel S, Singh Kuldev, Stein Joshua D, Vollrath Douglas, Weinreb Robert N, Wollstein Gadi, Yaspan Brian L, Yoneyama Sachiko, Zack Don, Zhang Kang, Pericak-Vance Margaret, Pasquale Louis R, Haines Jonathan L
Abstract excerpt
Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes,...
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