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Article

Genome-wide genetic interaction analysis of glaucoma using expert knowledge derived from human phenotype networks.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2015

Hu Ting, Darabos Christian, Cricco Maria E, Kong Emily, Moore Jason H

Abstract excerpt

The large volume of GWAS data poses great computational challenges for analyzing genetic interactions associated with common human diseases. We propose a computational framework for characterizing epistatic interactions among large sets of genetic attributes in GWAS data. We build the human phenotype network (HPN) and focus around a disease of interest. In this study, we use the GLAUGEN glaucoma GWAS dataset and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25592582
PMCID: PMC4299930

Genes

HPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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