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Article

PtdIns(4,5)P2 signaling regulates ATG14 and autophagy.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2016

Tan Xiaojun, Thapa Narendra, Liao Yihan, Choi Suyong, Anderson Richard A

Abstract excerpt

Autophagy is a regulated self-digestion pathway with fundamental roles in cell homeostasis and diseases. Autophagy is regulated by coordinated actions of a series of autophagy-related (ATG) proteins. The Barkor/ATG14(L)-VPS34 (a class III phosphatidylinositol 3-kinase) complex and its product phosphatidylinositol 3-phosphate [PtdIns(3)P] play key roles in autophagy initiation. ATG14 contains a C-terminal...

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Share to Adaptor Proteins, Vesicular Transport
Share to Autophagy-Related Protein 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27621469
DOI: 10.1073/pnas.1523145113
PMCID: PMC5047215

Genes

ATG14
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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