Article
Atg14L recruits PtdIns 3-kinase to the ER for autophagosome formation.
Autophagy - 1 Apr 2011
Noda Takeshi, Matsunaga Kohichi, Yoshimori Tamotsu
Abstract excerpt
Divergent phosphoinositides are generated to characterize specific organelles and recruit specific effector proteins to these sites. For example, phosphatidylinositol-3-phosphate (PtdIns(3)P) is a typical endosome marker and recruits many types of PtdIns(3)P binding proteins such as EEA1, Hrs, and sorting nexins, which are critical in endosomal functions. Likewise, the plasma membrane contains PtdIns(4,5)P₂,...
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