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Article

A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage.

Molecular cell - 6 Oct 2016

Xue Zhihong, Hennelly Scott, Doyle Boryana, Gulati Arune A, Novikova Irina V, Sanbonmatsu Karissa Y, Boyer Laurie A

Abstract excerpt

Long non-coding RNAs (lncRNAs) are an emerging class of transcripts that can modulate gene expression; however, their mechanisms of action remain poorly understood. Here, we experimentally determine the secondary structure of Braveheart (Bvht) using chemical probing methods and show that this ∼590 nt transcript has a modular fold. Using CRISPR/Cas9-mediated editing of mouse embryonic stem cells, we find that...

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Identifiers

PMID: 27618485
DOI: 10.1016/j.molcel.2016.08.010
PMCID: PMC6728430

Genes

CNBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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