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Article

Broad HIV-1 inhibition in vitro by vaccine-elicited CD8+ T cells in African adults

1 Jan 2016

Abstract excerpt

We are developing a pan-clade HIV-1 T-cell vaccine HIVconsv, which could complement Env vaccines for prophylaxis and be a key to HIV cure. Our strategy focuses vaccine-elicited effector T-cells on functionally and structurally conserved regions (not full-length proteins and not only epitopes) of the HIV-1 proteome, which are common to most global variants and which, if mutated, cause a replicative fitness loss....

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PMID: 27617268
DOI: 10.1038/mtm.2016.61

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