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Article

Investigation of TLR2 and TLR4 Polymorphisms and Sepsis Susceptibility: Computational and Experimental Approaches.

International journal of molecular sciences - 19 Sept 2022

Behairy Mohammed Y, Abdelrahman Ali A, Toraih Eman A, Ibrahim Emad El-Deen A, Azab Marwa M, Sayed Anwar A, Hashem Hany R

Abstract excerpt

Toll-like receptors (TLR) play an eminent role in the regulation of immune responses to invading pathogens during sepsis. TLR genetic variants might influence individual susceptibility to developing sepsis. The current study aimed to investigate the association of genetic polymorphisms of the TLR2 and TLR4 with the risk of developing sepsis with both a pilot study and in silico tools. Different in silico tools...

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Identifiers

PMID: 36142893
DOI: 10.3390/ijms231810982
PMCID: PMC9504743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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