Article
Mechanisms of neuronal cell death in Huntington's disease.
Cytogenetic and genome research - 1 Jan 2003
Sawa A, Tomoda T, Bae B-I
Abstract excerpt
Huntington's disease (HD) is a genetically dominant neurodegenerative condition caused by an unique mutation in the disease gene huntingtin. Although the Huntington protein (Htt) is ubiquitously expressed, expansion of the polyglutamine tract in Htt leads to the progressive loss of specific neuronal subpopulations in HD brains. In this article, we will summarize the current understanding on mechanisms of how...
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