Article
A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2016
Girard-Bock Camille, Benoit-Biancamano Marie-Odile, Villeneuve Lyne, Desjardins Sylvie, Guillemette Chantal
Abstract excerpt
The UDP glucuronosyltransferase (UGT) superfamily comprises glycoproteins that reside in the endoplasmic reticulum membranes and that undergo post-translational modifications (PTMs). UGT2B7 is of particular interest because of its action on a wide variety of drugs. Most studies currently survey common variants and examine only a small fraction of the genetic diversity; however, rare variants (frequency <1%) might...
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