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The Polymorphic Variant P24T of UDP-Glucuronosyltransferase 1A4 and Its Unusual Consequences.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2015

Troberg Johanna, Finel Moshe

Abstract excerpt

The P24T polymorphic variant of the human UDP-glucuronosyltransferase 1A4 (UGT1A4*2, 70C>A) occurs within the signal peptide, five amino acids upstream of the cleavage site and the start of the mature protein. Bioinformatic analysis of the variant suggested that the signal peptide of part of the translated protein is cleaved two residues upstream of the regular site, whereas the rest is cleaved as usual. To test...

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PMID: 26329791
DOI: 10.1124/dmd.115.065680

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