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Article

Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity.

Molecular pharmacology - 1 Dec 2020

Nair Pramod C, Chau Nuy, McKinnon Ross A, Miners John O

Abstract excerpt

Enzymes of the human UDP-glycosyltransferase (UGT) superfamily typically catalyze the covalent addition of the sugar moiety from a UDP-sugar cofactor to relatively low-molecular weight lipophilic compounds. Although UDP-glucuronic acid (UDP-GlcUA) is most commonly employed as the cofactor by UGT1 and UGT2 family enzymes, UGT2B7 and several other enzymes can use both UDP-GlcUA and UDP-glucose (UDP-Glc), leading to...

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PMID: 33008919
DOI: 10.1124/molpharm.120.000104

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