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Article

Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors.

Blood cancer journal - 9 Sept 2016

Venton G, Pérez-Alea M, Baier C, Fournet G, Quash G, Labiad Y, Martin G, Sanderson F, Poullin P, Suchon P, Farnault L, Nguyen C, Brunet C, Ceylan I, Costello R T

Abstract excerpt

The vast majority of patients with acute myeloid leukemia (AML) achieve complete remission (CR) after standard induction chemotherapy. However, the majority subsequently relapse and die of the disease. A leukemia stem cell (LSC) paradigm has been invoked to explain this failure of CR to reliably translate into cure. Indeed, LSCs are highly enriched in CD34+CD38- leukemic cells that exhibit positive aldehyde...

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Identifiers

PMID: 27611922
DOI: 10.1038/bcj.2016.78
PMCID: PMC5056970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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