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Article

The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients.

International journal of cancer - 1 Aug 2015

Hoang Van T, Buss Eike C, Wang Wenwen, Hoffmann Isabel, Raffel Simon, Zepeda-Moreno Abraham, Baran Natalia, Wuchter Patrick, Eckstein Volker, Trumpp Andreas, Jauch Anna, Ho Anthony D, Lutz Christoph

Abstract excerpt

To understand the precise disease driving mechanisms in acute myeloid leukemia (AML), comparison of patient matched hematopoietic stem cells (HSC) and leukemia stem cells (LSC) is essential. In this analysis, we have examined the value of aldehyde dehydrogenase (ALDH) activity in combination with CD34 expression for the separation of HSC from LSC in 104 patients with de novo AML. The majority of AML patients (80...

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Identifiers

PMID: 25545165
DOI: 10.1002/ijc.29410
PMCID: PMC4755039

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