Article
Association of acute myeloid leukemia's most immature phenotype with risk groups and outcomes.
Haematologica - 1 May 2016
Gerber Jonathan M, Zeidner Joshua F, Morse Sarah, Blackford Amanda L, Perkins Brandy, Yanagisawa Breann, Zhang Hao, Morsberger Laura, Karp Judith, Ning Yi, Gocke Christopher D, Rosner Gary L, Smith B Douglas, Jones Richard J
Abstract excerpt
The precise phenotype and biology of acute myeloid leukemia stem cells remain controversial, in part because the "gold standard" immunodeficient mouse engraftment assay fails in a significant fraction of patients and identifies multiple cell-types in others. We sought to analyze the clinical utility of a novel assay for putative leukemia stem cells in a large prospective cohort. The leukemic clone's most...
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