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Article

Polysialic acid enhances the migration and invasion of human cytotrophoblasts

3 Dec 2012

Abstract excerpt

Polysialic acid (polySia) is a large, cell-surface linear homopolymer composed of α2,8-linked sialic acid residues. Most extensively studied in the nervous system, this unique glycan modulates development by enhancing cell migration and regulating differentiation. PolySia also functions in developing and adult immune systems and is a signature of many cancers. In this study, we demonstrated that human placental...

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PMID: 23208007
DOI: 10.1093/glycob/cws162

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