Article
Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension.
Oncotarget - 27 Sept 2016
Peixoto Andreia, Fernandes Elisabete, Gaiteiro Cristiana, Lima Luís, Azevedo Rita, Soares Janine, Cotton Sofia, Parreira Beatriz, Neves Manuel, Amaro Teresina, Tavares Ana, Teixeira Filipe, Palmeira Carlos, Rangel Maria, Silva André M N, Reis Celso A, Santos Lúcio Lara, Oliveira Maria José, Ferreira José Alexandre
Abstract excerpt
Invasive bladder tumours express the cell-surface Sialyl-Tn (STn) antigen, which stems from a premature stop in protein O-glycosylation. The STn antigen favours invasion, immune escape, and possibly chemotherapy resistance, making it attractive for target therapeutics. However, the events leading to such deregulation in protein glycosylation are mostly unknown. Since hypoxia is a salient feature of advanced stage...
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