Article
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia.
PloS one - 1 Jan 2016
Mendonça Belmont Taciana Furtado de, do Ó Kleyton Palmeira, Soares da Silva Andreia, de Melo Vilar Kamila, Silva Medeiros Fernanda, Silva Vasconcelos Luydson Richardson, Mendonça Dos Anjos Ana Claudia, Domingues Hatzlhofer Betânia Lucena, Pitta Maíra Galdino da Rocha, Bezerra Marcos André Cavalcanti, Araújo Aderson da Silva, de Melo Rego Moacyr Jesus Barreto, Moura Patrícia, Cavalcanti Maria do Socorro Mendonça
Abstract excerpt
INTRODUCTION: Patients with sickle cell anemia (SCA) may present chronic hemolytic anemia, vaso-occlusion and respiratory tract infection (RTI) episodes. Galectin-3 (GAL-3) is a multifunctional protein involved in inflammation, apoptosis, adhesion and resistance to reactive oxygen species. Studies point to a dual role for GAL-3 as both a circulation damage-associated molecular pattern and a cell membrane...
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