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Article

Association of PON1 gene polymorphisms, paraoxonase 1 gene expression and activity in Egyptian children and adolescents with sickle cell disease.

BMC pediatrics - 21 Mar 2026

Hanna Diana, I Risha Amr, M Eldaly Mai, Ragab Hosnia, Sakr Maha Mahmoud Hamed, Nafea Alaa, Noah Maha Abdelaziz, Abdelmoneim Hala Mohammed Amin, Saadawy Sara F

Abstract excerpt

INTRODUCTION: Sickle cell disease (SCD) is defined by chronic oxidative stress, hemolysis, vaso-occlusive crisis (VOC), endothelial injury, and end-organ damage. Paraoxonase1 (PON-1) serves a significant function as an anti-inflammatory and antioxidant agent. This study investigates PON1c.55L > M and PON1c.192Q > R polymorphism frequency in Egyptian children and adolescents with SCD, as well as the impact of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41862865
DOI: 10.1186/s12887-026-06597-w
PMCID: PMC13063545

Genes

SCD
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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