Article
A genome-wide association study of circulating galectin-3.
PloS one - 1 Jan 2012
de Boer Rudolf A, Verweij Niek, van Veldhuisen Dirk J, Westra Harm-Jan, Bakker Stephan J L, Gansevoort Ron T, Muller Kobold Anneke C, van Gilst Wiek H, Franke Lude, Mateo Leach Irene, van der Harst Pim
Abstract excerpt
Galectin-3 is a lectin involved in fibrosis, inflammation and proliferation. Increased circulating levels of galectin-3 have been associated with various diseases, including cancer, immunological disorders, and cardiovascular disease. To enhance our knowledge on galectin-3 biology we performed the first genome-wide association study (GWAS) using the Illumina HumanCytoSNP-12 array imputed with the HapMap 2 CEU...
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