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Genetic variants in LGALS3 are related to lower galectin-3 serum levels and clinical outcomes in systemic sclerosis patients: A case-control study.

Autoimmunity - 1 Jun 2021

Cunha Eudes Gustavo Constantino, de Lima Camilla Albertina Dantas, Vilar Kamila de Melo, Nóbrega Marcelo Francisco de, Almeida Anderson Rodrigues de, Pereira Michelly Cristiny, Dantas Andréa Tavares, Gonçalves Rafaela Silva Guimarães, Rêgo Moacyr Jesus Barreto de Melo, Duarte Angela Luzia Branco Pinto, Pitta Maira Galdino da Rocha

Abstract excerpt

INTRODUCTION: Systemic sclerosis (SSc) is a rare complex disease characterized by vascular damage, autoimmunity, and extensive skin and internal organs fibrosis. Galectin-3 (Gal-3) is encoded by gene LGALS3 (Lectin, Galactoside-Binding, Soluble, 3; 14q22.3) and it has been reported to play a central role in self-tolerance, inflammation, and fibrosis. OBJECTIVE: To investigate associations among LGALS3 single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33973825
DOI: 10.1080/08916934.2021.1919881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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