Article
Pre-mRNA splicing in cancer: the relevance in oncogenesis, treatment and drug resistance.
Expert opinion on drug metabolism & toxicology - 1 May 2015
Wojtuszkiewicz Anna, Assaraf Yehuda G, Maas Marielle J P, Kaspers Gertjan J L, Jansen Gerrit, Cloos Jacqueline
Abstract excerpt
INTRODUCTION: Aberrant pre-mRNA splicing in cancer is emerging as an important determinant of oncogenesis, response to treatment and anticancer drug resistance. At the same time, the spliceosome has become a target for a novel class of pre-clinical chemotherapeutics with a potential future application in cancer treatment. Taken together, these findings offer novel opportunities for the enhancement of the efficacy...
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