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Article

Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease

13 May 2021

Abstract excerpt

RNA splicing is the enzymatic process by which non-protein coding sequences are removed from RNA to produce mature protein-coding mRNA. Splicing is thereby a major mediator of proteome diversity as well as a dynamic regulator of gene expression. Genetic alterations disrupting splicing of individual genes or altering the function of splicing factors contribute to a wide range of human genetic diseases as well as...

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PMID: 33994320
DOI: 10.1016/j.molmed.2021.04.005

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