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Article

RNA Splicing: Basic Aspects Underlie Antitumor Targeting.

Recent patents on anti-cancer drug discovery - 1 Jan 2020

Fergany Alzahraa A M, Tatarskiy Victor V

Abstract excerpt

BACKGROUND: RNA splicing, a fundamental step in gene expression, is aimed at intron removal and ordering of exons to form the protein's reading frame. OBJECTIVE: This review is focused on the role of RNA splicing in cancer biology; the splicing abnormalities that lead to tumor progression emerge as targets for therapeutic intervention. METHODS: We discuss the role of aberrant mRNA splicing in carcinogenesis and...

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PMID: 32900350
DOI: 10.2174/1574892815666200908122402

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