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A significant, functional and replicable risk KTN1 variant block for schizophrenia.

Scientific reports - 8 Mar 2023

Mao Qiao, Lin Xiandong, Yin Qin, Liu Ping, Zhang Yong, Qu Shihao, Xu Jianying, Cheng Wenhong, Luo Xinqun, Kang Longli, Taximaimaiti Reyisha, Zheng Chengchou, Zhang Huihao, Wang Xiaoping, Ren Honggang, Cao Yuping, Lin Jie, Luo Xingguang

Abstract excerpt

Cortical and subcortical structural alteration has been extensively reported in schizophrenia, including the unusual expansion of gray matter volumes (GMVs) of basal ganglia (BG), especially putamen. Previous genome-wide association studies pinpointed kinectin 1 gene (KTN1) as the most significant gene regulating the GMV of putamen. In this study, the role of KTN1 variants in risk and pathogenesis of...

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PMID: 36890161
DOI: 10.1038/s41598-023-27448-z
PMCID: PMC9995530

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