Article
Reduced cortical thickness is associated with the glutamatergic regulatory gene risk variant DAOA Arg30Lys in schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2011
Schultz C Christoph, Nenadic Igor, Koch Kathrin, Wagner Gerd, Roebel Martin, Schachtzabel Claudia, Mühleisen Thomas W, Nöthen Markus M, Cichon Sven, Deufel Thomas, Kiehntopf Michael, Rietschel Marcella, Reichenbach Jürgen R, Sauer Heinrich, Schlösser Ralf G M
Abstract excerpt
In light of current etiological concepts the glutamatergic system plays an essential role for the pathophysiology of the disorder, offering multiple options for new treatment strategies. The D-amino oxidase activator (DAOA) gene is closely connected to the glutamatergic system and its therapeutic and pathophysiological relevance for schizophrenia is therefore intensively debated. In a further step to shed light...
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