Article
Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2016
Price Aryn A, Tedesco Dana, Prasad Mona R, Workowski Kimberly A, Walker Christopher M, Suthar Mehul S, Honegger Jonathan R, Grakoui Arash
Abstract excerpt
Maternal innate and adaptive immune responses are modulated during pregnancy to concurrently defend against infection and tolerate the semiallogeneic fetus. The restoration of these systems after childbirth is poorly understood. We reasoned that enhanced innate immune activation may extend beyond gestation while adaptive immunity recovers. To test this hypothesis, the transcriptional profiles of total peripheral...
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