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Article

Baby's First Macrophage: Temporal Regulation of Hofbauer Cell Phenotype Influences Ligand-Mediated Innate Immune Responses across Gestation.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2020

Swieboda Dominika, Johnson Erica L, Beaver Jacob, Haddad Lisa, Enninga Elizabeth Ann L, Hathcock Matthew, Cordes Sarah, Jean Valerie, Lane Ivy, Skountzou Ioanna, Chakraborty Rana

Abstract excerpt

The importance of fetal placental macrophages (Hofbauer cell [HCs]) is underscored by their appearance 18 d postconception and maintenance through term; however, how human HCs evolve during healthy pregnancy and how microenvironment and ontogeny impact phenotype and function remain unknown. In this study, we comprehensively classify human HCs ex vivo, interrogate phenotypic plasticity, and characterize antiviral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32213562
DOI: 10.4049/jimmunol.1901185
PMCID: PMC7870092

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