Article
Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia.
EBioMedicine - 1 Sept 2020
Wedenoja Satu, Yoshihara Masahito, Teder Hindrek, Sariola Hannu, Gissler Mika, Katayama Shintaro, Wedenoja Juho, Häkkinen Inka M, Ezer Sini, Linder Nina, Lundin Johan, Skoog Tiina, Sahlin Ellika, Iwarsson Erik, Pettersson Karin, Kajantie Eero, Mokkonen Mikael, Heinonen Seppo, Laivuori Hannele, Krjutškov Kaarel, Kere Juha
Abstract excerpt
BACKGROUND: Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other genes regulating maternal immune responses. METHODS: We assessed sex ratios and regulatory HLA-G haplotypes in population cohorts and series of preeclampsia and stillbirth. We studied placental...
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