Article

Interferon lambda signals in maternal tissues to exert protective and pathologic effects in a gestational-stage dependent manner

2022-01-05

Abstract excerpt

<h4>ABSTRACT</h4> Interferon lambda (IFN-λ, type III IFN) is constitutively secreted from human placental cells in culture and reduces Zika virus (ZIKV) transplacental transmission in mice. However, the roles of IFN-λ during healthy pregnancy and in restricting congenital infection remain unclear. Here we used mice lacking the IFN-λ receptor ( Ifnlr1 -/- ) to generate pregnancies lacking either maternal or fetal...

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Identifiers and source

Literature Corpus work: 959e7911-faa9-5ee0-b513-d511ecb33cb0
DOI: 10.1101/2022.01.04.475019

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