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Article

Influence of IFNL3 and HLA-DPB1 genotype on postpartum control of hepatitis C virus replication and T-cell recovery.

Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2016

Honegger Jonathan R, Tedesco Dana, Kohout Jennifer A, Prasad Mona R, Price Aryn A, Lindquist Tera, Ohmer Samantha, Moore-Clingenpeel Melissa, Grakoui Arash, Walker Christopher M

Abstract excerpt

Chronic hepatitis C virus (HCV) infection is characterized by exhaustion of virus-specific T-cells and stable viremia. Pregnancy is an exception. Viremia gradually climbs during gestation but sometimes declines sharply in the months following delivery. Here, we demonstrated that postpartum HCV control was associated with enhanced virus-specific T-cell immunity. Women with viral load declines of at least 1 log10...

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Share to Hepatitis C, Chronic
Share to HLA-DP beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Cellular

Share to Intracellular Signaling Peptides and Proteins

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Share to T-Lymphocytes

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Source

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Identifiers

PMID: 27601657
DOI: 10.1073/pnas.1602337113
PMCID: PMC5035892

Genes

IFNL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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