Article
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2005
Tettelin Hervé, Masignani Vega, Cieslewicz Michael J, Donati Claudio, Medini Duccio, Ward Naomi L, Angiuoli Samuel V, Crabtree Jonathan, Jones Amanda L, Durkin A Scott, Deboy Robert T, Davidsen Tanja M, Mora Marirosa, Scarselli Maria, Margarit y Ros Immaculada, Peterson Jeremy D, Hauser Christopher R, Sundaram Jaideep P, Nelson William C, Madupu Ramana, Brinkac Lauren M, Dodson Robert J, Rosovitz Mary J, Sullivan Steven A, Daugherty Sean C, Haft Daniel H, Selengut Jeremy, Gwinn Michelle L, Zhou Liwei, Zafar Nikhat, Khouri Hoda, Radune Diana, Dimitrov George, Watkins Kisha, O'Connor Kevin J B, Smith Shannon, Utterback Teresa R, White Owen, Rubens Craig E, Grandi Guido, Madoff Lawrence C, Kasper Dennis L, Telford John L, Wessels Michael R, Rappuoli Rino, Fraser Claire M
Abstract excerpt
The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single genome does not reflect how genetic variability drives pathogenesis within a bacterial species and also limits genome-wide screens for vaccine candidates or for antimicrobial targets. We have generated the genomic...
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