Article
FTO genotype impacts food intake and corticolimbic activation.
The American journal of clinical nutrition - 1 Feb 2018
Melhorn Susan J, Askren Mary K, Chung Wendy K, Kratz Mario, Bosch Tyler A, Tyagi Vidhi, Webb Mary F, De Leon Mary Rosalynn B, Grabowski Thomas J, Leibel Rudolph L, Schur Ellen A
Abstract excerpt
Background: Variants in the first intron of the fat mass and obesity-associated (FTO) gene increase obesity risk. People with "high-risk" FTO genotypes exhibit preference for high-fat foods, reduced satiety responsiveness, and greater food intake consistent with impaired satiety. Objective: We sought central nervous system mechanisms that might underlie impaired satiety perception in people with a higher risk of...
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