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Article

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response.

Toxins - 2 Sept 2016

Jandhyala Dakshina M, Wong John, Mantis Nicholas J, Magun Bruce E, Leong John M, Thorpe Cheleste M

Abstract excerpt

Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2. We had a novel zak-/- mouse generated to study the role of ZAK signaling in vivo during ricin intoxication. To characterize this murine strain, we intoxicated zak-/- and zak+/+ bone marrow-derived murine...

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Identifiers

PMID: 27598200
DOI: 10.3390/toxins8090259
PMCID: PMC5037485

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