Caspase-3 protects stressed organs against cell death.

Abstract excerpt

The ability to generate appropriate defense responses is crucial for the survival of an organism exposed to pathogenesis-inducing insults. However, the mechanisms that allow tissues and organs to cope with such stresses are poorly understood. Here we show that caspase-3-knockout mice or caspase inhibitor-treated mice were defective in activating the antiapoptotic Akt kinase in response to various chemical and...

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• Cardiomyopathies
• Caspase 3
• Colitis
• Dextran Sulfate
• Doxorubicin