Article

Defining critical roles for ZBP1 in PANoptosis utilizing a novel genetic tool for disease modeling and therapeutic development

2026-05-21

Abstract excerpt

Innate immunity and innate immune cell death provide a critical first line of defense against disease. However, excess cell death leads to pathological inflammation. ZBP1 is an innate immune sensor that is central to this balance between defense and inflammation as a driver of inflammatory lytic cell death, PANoptosis. Activation of ZBP1-dependent PANoptosis downstream of diverse triggers has roles in both host de...

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Literature Corpus work: 63a717ef-d499-5558-a8b9-5acc04e05d4e
DOI: 10.64898/2026.05.19.726380

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