Article
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Science (New York, N.Y.) - 15 Jul 2022
Robinson Kim S, Toh Gee Ann, Rozario Pritisha, Chua Rae, Bauernfried Stefan, Sun Zijin, Firdaus Muhammad Jasrie, Bayat Shima, Nadkarni Rhea, Poh Zhi Sheng, Tham Khek Chian, Harapas Cassandra R, Lim Chrissie K, Chu Werncui, Tay Celest W S, Tan Kiat Yi, Zhao Tianyun, Bonnard Carine, Sobota Radoslaw, Connolly John E, Common John, Masters Seth L, Chen Kaiwen W, Ho Lena, Wu Bin, Hornung Veit, Zhong Franklin L
Abstract excerpt
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin and airway epithelium. Here, we report that human NLRP1 senses the ultraviolet B (UVB)- and toxin-induced ribotoxic stress response (RSR). Biochemically, RSR leads to the direct hyperphosphorylation of a human-specific disordered linker region of NLRP1 (NLRP1DR) by MAP3K20/ZAKα kinase and...
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