Article
The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury.
American journal of respiratory cell and molecular biology - 1 Jan 2002
McDowell Susan A, Mallakin Ali, Bachurski Cindy J, Toney-Earley Kenya, Prows Daniel R, Bruno Theresa, Kaestner Klaus H, Witte David P, Melin-Aldana Hector, Degen Sandra J F, Leikauf George D, Waltz Susan E
Abstract excerpt
Acute lung injury (ALI), a severe respiratory syndrome, develops in response to numerous insults and responds poorly to therapeutic intervention. Recently, cDNA microarray analyses were performed that indicated several pathogenic responses during nickel-induced ALI, including marked macrophage activation. Macrophage activation is mediated, in part, via the receptor tyrosine kinase Ron. To address the role of Ron...
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