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Article

Mutations at highly conserved residues in influenza A(H1N1)pdm09 virus affect neuraminidase activity.

Virus research - 2 Oct 2016

Romero-Beltran Lesly, Baker Steven F, Puerto-Solís Marylin, González-Losa Refugio, Conde-Ferraez Laura, Alvarez-Sánchez Leidi C, Martínez-Sobrido Luis, Ayora-Talavera Guadalupe

Abstract excerpt

Influenza virus neuraminidase (NA) plays a pivotal role during viral growth since its sialidase activity allows the efficient release of nascent virions from infected cells. Consequently, mutations in the NA catalytic site affecting sialic acid (SA) cleavage may influence the biological properties of influenza viruses. This study reports two amino acid substitutions (N386K and P431S) in the NA of the influenza...

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Identifiers

PMID: 27596738
DOI: 10.1016/j.virusres.2016.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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