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Comparison of early and recent influenza A(H1N1)pdm09 isolates harboring or not the H275Y neuraminidase mutation, in vitro and in animal models.

Antiviral research - 1 Nov 2018

Abed Yacine, Tu Véronique, Carbonneau Julie, Checkmahomed Liva, Venable Marie-Christine, Fage Clément, Marie-Ève-Hamelin, Dufresne Simon F, Kobinger Gary, Boivin Guy

Abstract excerpt

After 6 years of circulation in humans, a novel antigenic variant of influenza A(H1N1)pdm09 (i.e., A/Michigan/45/2015) emerged in 2015-16 and has predominated thereafter worldwide. Herein, we compared in vitro and in vivo properties of 2016 wild-type (WT) A/Michigan/45/15-like isolate and its H275Y neuraminidase (NA) variant to the original A/California/07/09-like counterparts. The H275Y mutation induced...

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Identifiers

PMID: 30219318
DOI: 10.1016/j.antiviral.2018.09.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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