Article
The universal epitope of influenza A viral neuraminidase fundamentally contributes to enzyme activity and viral replication.
The Journal of biological chemistry - 21 Jun 2013
Doyle Tracey M, Jaentschke Bozena, Van Domselaar Gary, Hashem Anwar M, Farnsworth Aaron, Forbes Nicole E, Li Changgui, Wang Junzhi, He Runtao, Brown Earl G, Li Xuguang
Abstract excerpt
The only universally conserved sequence among all influenza A viral neuraminidases is located between amino acids 222 and 230. However, the potential roles of these amino acids remain largely unknown. Through an array of experimental approaches including mutagenesis, reverse genetics, and growth...
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