Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Null allele mutants of trt-1, the catalytic subunit of telomerase in Caenorhabditis elegans, are less sensitive to Mn-induced toxicity and DAergic degeneration.

Neurotoxicology - 1 Dec 2016

Ijomone Omamuyovwi M, Miah Mahfuzur R, Peres Tanara V, Nwoha Polycarp U, Aschner Michael

Abstract excerpt

Exposure to manganese (Mn) represents an environmental risk factor for Parkinson's disease (PD). Recent evidence suggests that telomerase reverse transcriptase (TERT), the catalytic subunit of mammalian telomerase participates in non-telomeric functions and may play a role in cellular protection from oxidative stress and DNA damage. trt-1 is the catalytic subunit of telomerase in Caenorhabditis elegans (C....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorides
Share to Conditioning, Operant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine

Share to Dopamine Plasma Membrane Transport Proteins

Share to Locomotion

Share to Neurodegenerative Diseases

Share to Telomerase

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 27593554
DOI: 10.1016/j.neuro.2016.08.016

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Null allele mutants of trt-1, the catalytic subunit of telomerase in Caenorhabditis elegans, are less sensitive to Mn-induced toxicity and DAergic degeneration.PMID 27593554Read ↗

trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.Semantic proximity Read ↗

Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.Semantic proximity Read ↗

Dopamine controls the Sensitivity to Manganese induced Dopaminergic neurotoxicity in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.Semantic proximity Read ↗

A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress.Semantic proximity Read ↗

The Human LRRK2 Modulates the Age-Dependent Effects of Developmental Methylmercury Exposure in Caenorhabditis elegans.Semantic proximity Read ↗

A Caenorhabditis elegans model to study dopamine transporter deficiency syndrome.Semantic proximity Read ↗

Role of Caenorhabditis elegans AKT-1/2 and SGK-1 in Manganese Toxicity.Semantic proximity Read ↗

A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking.Semantic proximity Read ↗

Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant.Semantic proximity Read ↗

NDX-1 protein hydrolyzes 8-oxo-7, 8-dihydrodeoxyguanosine-5'-diphosphate to sanitize oxidized nucleotides and prevent oxidative stress in Caenorhabditis elegans.Semantic proximity Read ↗

Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.