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A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress.

Free radical biology & medicine - 1 Jun 2005

Arkblad Eva L, Tuck Simon, Pestov Nikolay B, Dmitriev Ruslan I, Kostina Maria B, Stenvall Jörgen, Tranberg Mattias, Rydström Jan

Abstract excerpt

Proton-translocating mitochondrial nicotinamide nucleotide transhydrogenase (NNT) was investigated regarding its physiological role in Caenorhabditis elegans. NNT catalyzes the reduction of NADP(+) by NADH driven by the electrochemical proton gradient, Deltap, and is thus a potentially important source of mitochondrial NADPH. Mitochondrial detoxification of reactive oxygen species (ROS) by glutathione-dependent...

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PMID: 15890626
DOI: 10.1016/j.freeradbiomed.2005.02.012

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NNT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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