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The Human LRRK2 Modulates the Age-Dependent Effects of Developmental Methylmercury Exposure in Caenorhabditis elegans.

Neurotoxicity research - 1 Oct 2022

Ke Tao, Tinkov Alexey A, Skalny Anatoly V, Santamaria Abel, Farina Marcelo, Rocha João B T, Bowman Aaron B, Aschner Michael

Abstract excerpt

Methylmercury (MeHg) neurotoxicity exhibits age-dependent effects with a latent and/or persistent neurotoxic effect on aged animals. Individual susceptibility to MeHg neurotoxicity is governed by both exposure duration and genetic factors that can magnify or mitigate the pathologic processes associated with this exposure. We previously showed the G2019S mutation of leucine-rich repeat kinase 2 (LRRK2) modulates...

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PMID: 35838907
DOI: 10.1007/s12640-022-00547-x

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